Endocrine Abstracts

Gonadotropin releasing hormone actively de-represses expression of the gonadotropin subunit genes through several actions that target the chromatin. We have shown in the past that both LHβ and FSHβ genes are repressed by histone deacetylases (HDACs) in αT3-1 gonadotrope cells and that this repression is overcome by exposure to GnRH which facilitates HDAC removal via CaMKI-mediated phosphorylation. At the LHβ gene promoter, both histone acetylation and phosp...